Proyectos actuales
Publicaciones destacadas
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HMCES corrupts replication fork stability during base excision repair in homologous recombination–deficient cells
Autores: Peña-Gómez, María José; Rodríguez-Martín, Yaiza; del Rio Oliva, Marta; Wijesekara Hanthi, Yodhara; Berrada, Sara; Freire, Raimundo; Masson, Jean Yves; Reyes, José Carlos; Costanzo, Vincenzo; Rosado, Iván V.
Science Advances (2025) -
FANCD2 maintains replication fork stability during misincorporation of the DNA demethylation products 5-hydroxymethyl-2’-deoxycytidine and 5-hydroxymethyl-2’-deoxyuridine
Autores: Peña-Gómez, María José; Moreno-Gordillo, Paula; Narmontė, Milda; García-Calderón, Clara B.; Rukšėnaitė, Audronė; Klimašauskas, Saulius; Rosado, Iván V.
Cell Death & Disease (2022) -
Mammals divert endogenous genotoxic formaldehyde into one-carbon metabolism
Autores: Burgos-Barragan, Guillermo; Wit, Niek; Meiser, Johannes; Dingler, Felix A.; Pietzke, Matthias; Mulderrig, Lee; Pontel, Lucas B.; Rosado, Ivan V.; Brewer, Thomas F.; Cordell, Rebecca L.; Monks, Paul S.; Chang, Christopher J.; Vazquez, Alexei; Patel, Ketan J.
Nature (2017) -
The Fanconi Anemia Pathway Protects Genome Integrity from R-loops
Autores: García-Rubio, María L.; Pérez-Calero, Carmen; Barroso, Sonia I.; Tumini, Emanuela; Herrera-Moyano, Emilia; Rosado, Iván V.; Aguilera, Andrés
PLOS Genetics (2015) -
Endogenous Formaldehyde Is a Hematopoietic Stem Cell Genotoxin and Metabolic Carcinogen
Autores: Pontel, Lucas B.; Rosado, Ivan V.; Burgos-Barragan, Guillermo; Garaycoechea, Juan I.; Yu, Rui; Arends, Mark J.; Chandrasekaran, Gayathri; Broecker, Verena; Wei, Wei; Liu, Limin; Swenberg, James A.; Crossan, Gerry P.; Patel, Ketan J.
Molecular Cell (2015) -
Formaldehyde catabolism is essential in cells deficient for the Fanconi anemia DNA-repair pathway
Autores: Rosado, Ivan V; Langevin, Frédéric; Crossan, Gerry P; Takata, Minoru; Patel, Ketan J
Nature Structural & Molecular Biology (2011)
