Intervenciones metabólicas para un envejecimiento saludable

Main Research Line:

In our current society, more than 50% of elderly humans suffer age-related disabilities that impede optimal quality of life and reduce life expectancy. These disabilities imply important suffering for aging individuals and their families. Therefore, there is an urgent need to develop more effective strategies to prevent and treat age-related diseases/disabilities. Our research goal is to identify novel therapeutically promising strategies able to improve the quality of life and life expectancy in humans.

We are currently investigating novel approaches to modulate metabolism and aging by two main molecular mechanisms. We are targeting the restriction of nuclear/cytosolic Acetyl Coenzyme A (Ac-CoA) levels in mammals. We are evaluating whether a chronic reduction on cytosolic/nuclear Ac-CoA levels using cytosolic Ac-CoA reducing agents, prevent and/or revert metabolic complications, and extend healthspan and lifespan in mammals. In brief, we are investigating the regenerative potential of ATP-citrate lyase inhibitors in tissue regeneration. Another line of research is evaluating the potential of the potentiation of sulfur metabolism on aging and age-related diseases. We are investigating different aspects of aging such as tissue regeneration, metabolic health, locomotor function, cancer and neurocognitive diseases.

Our research involves the use of laboratory mice using different experimental approaches ranging from acute treatments (single exposure to the intervention) to longevity assays in mice (3 year intervention). We determine alterations in different parameters of health during the different phases of life in mice. We also use the latest approaches to define the molecular mechanisms altered in aging and alterations produced by experimental treatments

Immunohistochemistry in brain

Immunocytochemistry in neuronal cultures.

Join us!

If you want to apply to our lab as a Master Student, PhD Students or Postdoc, send a motivation letter, CV and contact details to alejandro.martinmontalvo@cabimer.es

ResearcherID: C-2031-2017
Scopus: 25635883500

ORCID: 0000-0002-3886-5355

Current funding:

CSIC. La modulación de la oxidación de cisteínas como mecanismo relevante en la salud y el envejecimiento. Code: 202220I059

Ministry of Health and Innovation. El aumento en la S-sufihidración de cisteínas promovida por generadores intracelulares del sulfuro de hidrógeno como estrategia para conseguir un envejecimiento más saludable. Code: PID2021-123965OB-I00