The Department of Genome Biology is dedicated to investigating the molecular mechanisms that regulate the expression, maintenance, and evolution of chromosomes during the cell cycle, and how their dysregulation contributes to cancer and genetic disorders. Its work encompasses genome dynamics, including genomic instability, DNA replication, recombination, and repair, as well as the cellular response
to genetic damage. It also studies chromatin integrity, epigenetic modifications and gene expression, integrating genomic and epigenomic approaches using advanced computational tools. Genomic instability, common in congenital syndromes, rare diseases and processes such as ageing and cancer, is a central focus. In addition, it analyses regulatory networks involved in cell differentiation, tissue plasticity and signalling, which are essential
for maintaining cell homeostasis. Multidisciplinary teams collaborate closely on these lines of research within the framework of CABIMER, fostering innovation and discovery. This diversity fosters strong collaborations, promoting synergistic advances in the Department’s thematic areas within the broader context of CABIMER, and maximises the collective strengths of the groups, enhancing both innovation and discovery.
